Epigenetic Regulation of Neuroinflammation in Parkinson’s Disease

P 133: Neuroinflammation in Alzheimer ’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. Almost 47 million people suffer from dementia worldwide. AD accounts for approximately 60%–80% of all dementia cases. Three major pathologies characterize the disease: senile plaques, neurofibrillary tangles and inflammation. We review the literature on events contributing to the inflammat...

Epigenetic regulation in alcoholic liver disease.

Alcoholic liver disease (ALD) is characterized by steatosis or fat deposition in the liver and inflammation, which leads to cirrhosis and hepatocellular carcinoma. Induction of target genes without involving changes in DNA sequence seems to contribute greatly to liver injury. Chromatin modifications including alterations in histones and DNA, as well as post-transcriptional changes collectively ...

Onm-19: Role of Epigenetic in Transgenerarional Disease

Epigenetic alterations have been related to many biological processes and disease; however, the global epigenetic status of most cell types has not been investigated yet in detail. The ability of environmental factors to promote a phenotype or disease state not only in the individual exposed but also in subsequent progeny for successive generations is termed transgenerational inheritance. The m...

Epigenetic regulation of asthma and allergic disease

Epigenetics of asthma and allergic disease is a field that has expanded greatly in the last decade. Previously thought only in terms of cell differentiation, it is now evident the epigenetics regulate many processes. With T cell activation, commitment toward an allergic phenotype is tightly regulated by DNA methylation and histone modifications at the Th2 locus control region. When normal epige...

EPIGENETIC REGULATION OF METABOLIC DISEASE Catherine